1,136 research outputs found

    PCN42 COST EFFECTIVENESS OF FULVESTRANT AS AN ADDITIONAL ENDOCRINE STEP IN THE TREATMENT SEQUENCE FOR HORMONE RESPONSIVE ADVANCED BREAST CANCER

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    Bifurcation Phenomena. A Short Introductory Tutorial with Examples

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    The phase space geometry underlying roaming reaction dynamics

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    Observer design for a class of nonlinear systems combining dissipativity with interconnection and damping assignment

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    A nonlinear observer design approach is proposed that exploits and combines port-Hamiltonian systems and dissipativity theory. First, a passivity-based observer design using interconnection and damping assignment for time variant state affine systems is presented by applying output injection to the system such that the observer error dynamics takes a port-Hamiltonian structure. The stability of the observer error system is assured by exploiting its passivity properties. Second, this setup is extended to develop an observer design approach for a class of systems with a time varying state affine forward and a nonlinear feedback contribution. For a class of nonlinear systems, the theory of dissipative observers is adapted and combined with the results for the passivity-based observer design using interconnection and damping assignment. The convergence of the compound observer design is determined by a linear matrix inequality. The performance of both observer approaches is analyzed in simulation examples

    On the Mathematics of the Law of Mass Action

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    In 1864,Waage and Guldberg formulated the "law of mass action." Since that time, chemists, chemical engineers, physicists and mathematicians have amassed a great deal of knowledge on the topic. In our view, sufficient understanding has been acquired to warrant a formal mathematical consolidation. A major goal of this consolidation is to solidify the mathematical foundations of mass action chemistry -- to provide precise definitions, elucidate what can now be proved, and indicate what is only conjectured. In addition, we believe that the law of mass action is of intrinsic mathematical interest and should be made available in a form that might transcend its application to chemistry alone. We present the law of mass action in the context of a dynamical theory of sets of binomials over the complex numbers.Comment: 40 pages, no figure
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